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Multimodal intervention reduces opioid use in hospitalized patients with IBD

SAN ANTONIO — A series of interventions promoting guidance and appropriate therapy for pain management significantly reduced opioid use among hospitalized patients with inflammatory bowel disease, according to research presented at the American College of Gastroenterology Annual Meeting.Current data show that up to 70% of hospitalized patients with IBD receive opioids, although the drugs are…

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New HCV infection less common in MSM initiating PrEP

BOSTON — New incidences of hepatitis C virus infection among men who have sex with men, or MSM, who are actively using pre-exposure prophylaxis for HIV prevention appeared to be less common than previously shown, according to data presented at The Liver Meeting 2019.“There have been a number of studies showing that once pre-exposure prophylaxis…

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VIDEO: Shorter duration Mavyret safe, effective in all HCV genotypes

BOSTON — In this exclusive video from The Liver Meeting 2019, Robert S. Brown Jr., MD, MPH, of Weill Cornell Medical College, discusses the results of the EXPEDITION-8 trial, which demonstrated that treatment with Mavyret over 8 weeks was effective and had a favorable safety profile in patients with treatment-naive chronic hepatitis C virus genotypes…

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Selonsertib misses endpoint, provides future trial design insight

BOSTON — While selonsertib did not demonstrate efficacy as a monotherapy in patients with nonalcoholic steatohepatitis-related advanced fibrosis, data from the trial provided key insights for future trial design and potential for selonsertib in combination therapy, according to data presented at The Liver Meeting 2019.“It’s important to see what we can glean from a study…

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Hepatic encephalopathy tool detects minimal impairment in the elderly

BOSTON — In a multicenter study of older patients with cirrhosis, the EncephalApp tool accurately diagnosed cognitive impairment and hepatic encephalopathy, according to a presenter at The Liver Meeting 2019.“Patients with cirrhosis are growing older and increasing survival means that these patients are often diagnosed with cirrhosis at a later age,” Jasmohan S. Bajaj, MD,…

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Live zoster vaccine safe, effective in patients taking TNF inhibitors

ATLANTA — Data from the Varicella Zoster Vaccine study demonstrate that administering live, attenuated varicella vaccine to patients taking TNF inhibitors did not result in any safety events or disease flare after 6 weeks. In addition, there were no cases of varicella infection — either wild or vaccine type.“I’m very excited about the results of…

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Avelumab maintenance fails to extend OS in advanced gastric, gastroesophageal junction cancers

A randomized phase 3 trial designed to evaluate avelumab as first-line maintenance therapy for patients with unresectable, locally advanced or metastatic HER2-negative gastric or gastroesophageal junction cancer failed to meet its primary endpoints.The multicenter, open-label JAVELIN Gastric 100 study included 805 patients who had not received chemotherapy for metastatic or locally advanced disease. Investigators enrolled…

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AI identifies pathogenesis pathways, risk for Crohn’s disease

AVA,Dx, a machine learning method for risk prediction of Crohn’s disease, revealed new potential CD genes and accurately identified the disease in a group of more than 3,000 individuals, according to a recent study.Yana Bromberg, PhD, associate professor in the department of biochemistry and microbiology at Rutgers University New Brunswick, and colleagues used person-specific coding…

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‘Embrace the chaos’: Advice on integrating work, life

BOSTON — In this exclusive video from The Liver Meeting 2019, Monica Tincopa, MD, MSc, a junior faculty member in the department of transplant hepatology at the University of Michigan, highlights a talk she gave during a career development workshop that focused on making time for both personal and professional lives.“What I really tried to…