Combination therapy trial for locally advanced, metastatic HCC underway

CStone Pharmaceuticals and Blueprint Medicines Corporation announced the first patient dosed in a phase 1b/2 trial of fisobatinib in combination with CS1001 for the treatment of locally advanced or metastatic hepatocellular carcinoma, according to a press release.Investigators will assess the potential for two complementary treatment approaches including precision therapy and immune-oncology therapy to enhance anti-tumor…

‘Number to treat’ with UDCA may improve survival rates in PBC

While the absolute clinical efficacy of ursodeoxycholic acid for primary biliary cholangitis varied by baseline prognostic characteristics, study results showed generally high rates of liver transplant-free survival and overall survival.“These results provide a clear understanding of the clinical importance of optimized UDCA therapy for patients and doctors, thereby stimulating compliance and treatment uptake,” Maren H….

Culture, quarantine effectively identify contaminated duodenoscopes

First and even second time high-level disinfection may not be enough to eliminate bacterial contamination in duodenoscopes, but a culture and quarantine program can help identify which scopes need more attention, according to study results.“Because of the concerns of duodenoscope-transmitted infections, in 2015 our institution re-evaluated duodenoscope cleaning and reprocessing practices and instituted [high-level disinfection]…

Remicade is top among biologic-naive patients with UC

Remicade ranked highest for induction of remission and endoscopic improvement among biologic-naive patients, according to a meta-analysis of treatments for moderately to severely active ulcerative colitis.In the same study, Stelara (ustekinumab, Janssen) and Xeljanz (tofacitinib, Pfizer) had the best results among patients who had been previously exposed to anti-TNF therapy.“Several treatment options are now available…

Five ways climate change impacts health — and how clinicians can mitigate its effect

Although the link between climate change and health is “becoming increasingly clear,” the medical community is generally unaware of how much climate change is impacting patients today, experts told Healio Primary Care.“The knowledge gap is a huge issue,” Neelu Tummala, MD, a physician within the otolaryngology department at George Washington University’s Medical Faculty Associates, told…