Mortality with two stress ulcer prophylaxis treatments did not differ in critically ill patients

Among critically ill patients requiring mechanical ventilation, 90-day in-hospital mortality rates did not differ significantly between those who received proton pump inhibitors and those who received histamine-2 receptor blockers for stress ulcer prophylaxis, new data published in JAMA indicate.Proton pump inhibitors (PPIs) are associated with various immunosuppressive effects that could lead to an increased risk…

Abdominal pain differs between IBS subtypes

The presentation and characteristics of abdominal pain are not the same among the different subtypes of irritable bowel syndrome, according to study results.Eric D. Shah, MD, MBA, from the section of gastroenterology and hepatology at Dartmouth-Hitchcock Medical Center, and colleagues wrote that it is currently unknown if diarrhea- and constipation-predominant IBS carry different burdens of…

Constipation may lead to uremic toxins in patients with CKD

Constipation was associated with the production of the uremic toxin p-cresylsulfate — but not indoxyl sulfate — in patients with chronic kidney disease, according to a published study.As Christiane Ishikawa Ramos, PhD, of the Universidade Federal de Sao Paul in Brazil, and colleagues wrote, constipation is common in patients with CKD and may lead to…

Microscopic colitis may increase risk for incident IBD

Patients with microscopic colitis were at increased risk for incident inflammatory bowel disease, according to study results.Hamed Khalili, MD, of the Crohn’s and Colitis Center at Massachusetts General Hospital, and colleagues wrote that some experts have suggested that microscopic colitis is a weaker form of IBD that can transform in some patients.“The disease is distinct…

Five ways to maximize EHR use

Electronic health records promised to save time but instead, findings show that primary care physicians spend almost 6 hours a day on them.“EHRs are zapping into our soul, zapping into our personal time with family,” Richard M. Wardrop III, MD, PhD, professor and vice chair of education and faculty development at the University of Mississippi…