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FDA approves Enhertu for gastric cancer subset

The FDA approved fam-trastuzumab deruxtecan-nxki for treatment of certain patients with gastric or gastroesophageal adenocarcinoma.The approval applies to use of the agent by adults with locally advanced or metastatic HER2-positive disease who received a prior trastuzumab (Herceptin, Genentech)-based regimen.Fam-trastuzumab deruxtecan-nxki (Enhertu; AstraZeneca, Daiichi Sankyo) is a novel antibody-drug conjugate with three components: a humanized anti-HER2…

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Blood test shows promise for early detection of colorectal adenomas

A noninvasive multimodal blood test demonstrated high sensitivity and specificity for the detection of colorectal advanced neoplasia, according to prospective study results presented at Gastrointestinal Cancers Symposium.These findings suggest the blood test, FirstSight (CellMax Life), can be used to stratify individuals for screening or for post-polypectomy surveillance colonoscopy, according to the researchers.“Colonoscopic polypectomy is the…

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Intraperitoneal paclitaxel prolongs survival in gastric cancer with peritoneal metastases

The addition of intraperitoneal paclitaxel to systemic capecitabine and oxaliplatin appeared to benefit patients with gastric cancer and peritoneal metastases, according to study results presented at Gastrointestinal Cancers Symposium.“Peritoneal metastasis is a common problem in patients with gastric cancer, and this unfortunately is not effectively treated by systemic chemotherapy alone given the presence of the…

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HHS expands access to buprenorphine for opioid use disorder

HHS has released new guidance that the agency said will improve access to medication-assisted treatment for opioid use disorder.Specifically, physicians with a Drug Enforcement Administration (DEA) registration number are no longer required to apply for a separate waiver to prescribe buprenorphine for opioid use disorder (OUD) treatment. The guidance states that eligible physicians:“This is a…

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Validated risk score predicts post-transplant survival in HCC

Investigators developed a validated risk score to predict post-transplant survival for patients with hepatocellular carcinoma that will help prioritize patients based on predicted survival, according to study results.”In the United States, all patients with liver cancer or HCC who are waitlisted for a transplant and meet [United Network for Organ Sharing (UNOS)] exception criteria receive…

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Women in the US at higher risk for food insecurity

Women in the United States were more likely to have food insecurity than men, according to study results.Christopher Ma, MD, MPH, from the division of gastroenterology and hepatology at the University of Calgary, and colleagues wrote that food insecurity can not only be more detrimental to women in their personal lives, but also their health.“Addressing…

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The race is on for medical treatment of NASH

Nonalcoholic steatohepatitis is the second leading indication for liver transplantation in the United States but there are currently no FDA-approved treatments available.Rohit Loomba, MD, MHSc, director of the NAFLD Research Center and director of hepatology, professor of medicine at the University of California, San Diego, told Healio Gastroenterology that in the next decade NASH will…

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Speaker: ‘Timing could not be better’ to boost diversity in health care

Contending that diversity among health care professionals is essential to providing the highest quality of care, a speaker at the American Society of Transplant Surgeons Winter Symposium outlined challenges and strategies for improvement.“Increasing diversity does not by itself increase effectiveness,” Anthony C. Watkins, MD, a transplant surgeon at NYU Langone Medical Center, said during a…