Steady rise in early-onset colorectal cancer among Blacks calls for renewed outreach

Black individuals have the highest incidence and mortality rates of colorectal cancer of any racial or ethnic group in the United States.Colorectal cancer has the third most diagnosed cancer in the U.S., with a 20% higher incidence among Black individuals compared with their white counterparts.Moreover, Black patients tend to present at a younger age and…

Children with active CD consume diet with significantly lower amount of fiber

Study results demonstrate diet may differentially influence the gut microbiome in children with Crohn’s disease, according to a presentation at the Crohn’s and Colitis Congress.“Both children with CD and healthy children in North America consume a Westernized diet which is low in fiber, more significantly low in children with active CD,” Jessica Breton, MD, from…

Ivosidenib confers clinical benefit in advanced cholangiocarcinoma subset

Ivosidenib modestly extended OS among patients with previously treated isocitrate dehydrogenase 1-mutated advanced cholangiocarcinoma, according to final results of the phase 3 ClarIDHy trial presented at Gastrointestinal Cancers Symposium.The agent also appeared well-tolerated compared with placebo.“Cholangiocarcinoma is a rare, aggressive malignancy with limited effective treatment options,” Andrew X. Zhu, MD, PhD, director of liver cancer…

Children treated with anti-TNF therapy at risk for weight gain, obesity

Children with inflammatory bowel disease who receive anti-tumor necrosis factor treatment were more likely to see BMI levels increase and incur a risk for obesity, according to a presentation at Crohn’s and Colitis Congress.“Crohn’s disease patients with anti-TNF exposure have a significant increase in BMI z score over time as compared to those unexposed and…

Allogeneic CAR T-cell therapy safe, clinically active in metastatic colorectal cancer

An allogeneic chimeric antigen T-cell therapy showed evidence of clinical activity among patients with metastatic colorectal cancer, according to results of a dose-escalation study presented at Gastrointestinal Cancers Symposium.No patients treated so far in the trial have experienced a serious adverse event or developed graft-versus-host disease, according to the study investigators.CYAD-101 (Celyad) is an investigational,…

Shared decision-making requires two-way information, numeracy literacy

To improve shared decision-making in care for patients with inflammatory bowel disease, the problem of numeracy – both among patients and providers – must be discussed, according to a presentation at Crohn’s and Colitis Congress.“In America, numeracy is a problem for everyone. Over 50% of Americans lack the minimum basic skills to apply math to…