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FDA warns of increased risk for heart-related issues, cancer linked to Xeljanz

The FDA has issued a safety alert warning patients and health providers of an increased risk for serious health-related problems and cancer linked to tofacitinib compared with TNF inhibitors among older patients.As part of the alert, the FDA has recommended that health care professionals consider the benefits and risks associated with tofacitinib (Xeljanz, Pfizer) when…

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FMT converts cancer immunotherapy non-responders to responders

Adding fecal microbiota transplantation to treatment in patients with programmed cell death protein 1 melanoma altered the gut microbiome and reprogrammed tumor microenvironment to overcome resistance to anti-programmed cell death protein 1 therapy, according to study results.“Our findings warrant further investigation in larger clinical trials to better identify microbial, circulating and intra-tumoral biomarkers to select…

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Tethered capsule provides high-quality images for Barrett’s esophagus

Researchers were able obtain high-quality images of Barrett’s esophagus using tethered capsule endomicroscopy, according to study results.Guillermo Tearney, MD, PhD, from the Wellman Center for Photomedicine at Massachusetts General Hospital, and colleagues wrote that the capsule, which uses optical coherence tomography, (OCT-TCE) provides 3D microscopic images of the esophagus for BE.“OCT-TCE does not require sedation,…

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Trial to evaluate combination of CAR-T and pembrolizumab for metastatic colorectal cancer

Although colorectal cancer mortality has declined steadily since the 1940s, the long-term prognosis for patients with late-stage metastatic disease has remained relatively poor.The 5-year survival rate for patients with metastatic colorectal cancer stands at 14%, according to American Cancer Society data.Researchers hope to address the unmet treatment needs of these patients by combining chimeric antigen…

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Q&A: ABIM offers solutions to address ‘earned mistrust’ in medical community

The public’s trust in the medical community is beginning to erode, but health care professionals can take action to help restore it, ABIM President and CEO Richard J. Baron, MD, MACP, told Healio Primary Care.“In recent years, we have seen many harmful attempts to undermine science and to sow doubt about medical evidence,” he said….