FDA approves Bylvay for treating progressive familial intrahepatic cholestasis

FDA approves Bylvay for treating progressive familial intrahepatic cholestasis

Albiero Pharma Inc. announced it received FDA approval for Bylvay to treat pruritus in all subtypes of progressive familial intrahepatic cholestasis.According to a press release, it is the first drug approved for PFIC.Bylvay (odevixibat) is a non-systemic ileal bile acid transport inhibitor. Odevixibat will not require refrigeration and is administered as a once-daily capsule or…

Q&A: Phase 1b trial will assess oral-administered vascular adhesion protein-1 inhibitor for NASH

Q&A: Phase 1b trial will assess oral-administered vascular adhesion protein-1 inhibitor for NASH

Terns Pharmaceuticals Inc. announced initiation of a phase 1b clinical trial assessing TERN-201 for the treatment of patients with nonalcoholic steatohepatitis.According to a press release, TERN-201 is an orally administered inhibitor of vascular adhesion protein-1 (VAP-1). The AVIATION trial is a multi-center, randomized, double-blind, dose-ranging, placebo-controlled, phase 1b clinical study of the safety, pharmacokinetics, pharmacodynamics…

Low-FODMAP, gluten-free diet improves IBS symptoms

Low-FODMAP, gluten-free diet improves IBS symptoms

Patients with irritable bowel syndrome had improved symptom severity and normalized gut microbiota while following a low-FODMAP diet combined with a gluten-free diet, according to data published in BMC Gastroenterology.“Recently, dietary components including wheat, gluten and fermentable oligo-di-monosaccharides and polyols have been suggested to play an essential role in the induction of IBS symptoms. Accordingly,…

High anemia risk persists decades after bariatric surgery

High anemia risk persists decades after bariatric surgery

Adults with obesity who undergo gastric bypass are five times more likely to develop anemia compared with those receiving nonsurgical obesity care, highlighting the importance of long-term adherence to nutritional supplementation.In an analysis of participants in the long-term Swedish Obese Subjects study, researchers also found that gastric banding and vertical-banded gastroplasty were each associated with…