DAAs with, without PIs yield similar outcomes in decompensated HCV cirrhosis

SAN DIEGO — Researchers reported similar clinical outcomes in patients with decompensated hepatitis C virus cirrhosis treated with direct-acting antivirals, with or without protease inhibitors, according to study results.“The current study reflects real world practice on PI-based DDAs where physicians may choose to initiate PI-based DAAs in view of limited treatment options besides liver transplantation,…

Black patients ‘not caught up’ to whites in early-onset CRC survival over 20-year period

SAN DIEGO — Five-year relative survival for early-onset colorectal cancer improved over a 20-year period only among white patients, with no improvements for Black, Asian or Hispanic patients, per data at Digestive Disease Week 2022.“Our most stunning finding was that even over a 20-year span, Blacks had not caught up to whites in surviving early-onset…

US surgeon general: Confronting burnout ‘must be a top national priority’

U.S. Surgeon General Vivek H. Murthy, MD, MBA, issued an advisory addressing the alarming rate of burnout among health care workers.“The nation’s health depends on the well-being of our health workforce,” Murthy said in an HHS press release. “Confronting the long-standing drivers of burnout among our health workers must be a top national priority. COVID-19…

VIDEO: RBX2660 restores microbiome, bile acid composition in C. difficile infection

SAN DIEGO — RBX2660, an investigational live biotherapeutic, restored microbiome and bile acid composition concurrent with clinical response in patients with Clostridioides difficile, according to research at Digestive Disease Week 2022.“This poster is three different takes on how RBX2660 is aimed at restoring the microbiome and the data that we saw in three clinical trials,”…

Increase in drug overdose donors led to steady transplant volume during COVID-19

SAN DIEGO — An increase in drug overdose donor utilization during the COVID-19 pandemic contributed to a steady transplant volume among all organ types, including liver transplants, according to a presenter at Digestive Disease Week 2022.“The continued pervasiveness of the opioid epidemic has led to the increased utilization of young, otherwise healthy [drug overdose donors…

Early-life dog ownership may protect against development of Crohn’s disease

SAN DIEGO — Dog ownership and close interactions with these pets in early childhood could help prevent later development of Crohn’s disease, according to data presented at Digestive Disease Week 2022.“Our study seems to add to others that have explored the ‘hygiene hypothesis’ which suggests that the lack of exposure to microbes early in life…