HBV-listed death rates surpass national average in coastal, Appalachian states

Individuals born in the United States made up nearly two-thirds of all hepatitis B-listed deaths, with death rates exceeding the national average in 13 states, according to research published in JAMA Network Open.“Annual national viral hepatitis surveillance reports have included hepatitis B mortality estimates since 2004, displaying state-level data since 2015. However, these reports lackedinformation…

Antibiotic use, certain gut bacteria affect CAR-T efficacy, toxicity

The use of broad-spectrum antibiotics in the month leading up to chimeric antigen receptor T-cell therapy led to poorer outcomes and increased treatment-related toxicities, study results showed.Certain types of gut bacteria had an impact on treatment efficacy and related toxicities among patients who received CAR-T for non-Hodgkin lymphoma or acute lymphoblastic leukemia, researchers reported.CAR T-cell…

VIDEO: Stelara can safely be used long-term to benefit patients with UC, Crohn’s

In a Healio video exclusive, Remo Panaccione, MD, discusses results from long-term, pooled analyses of adult patients treated with ustekinumab for inflammatory bowel disease.“We know that Stelara (ustekinumab, Janssen) is a highly effective therapy in inflammatory bowel disease when it’s either used first-line or in patients who have been exposed to other advanced therapies,” Panaccione,…