Dupixent bests placebo in clinical, histological outcomes in patients with EoE

CHARLOTTE, N.C. — Dupilumab improved clinical, symptomatic, histologic and endoscopic outcomes among patients treated for eosinophilic esophagitis, according to study results presented at the ACG Annual Scientific Meeting.“EoE is a chronic, progressive, type 2 inflammatory disease of the esophagus, leading to symptoms of esophageal dysfunction that can substantially affect quality of life. Some current treatment…

VIDEO: Guselkumab outperforms placebo for UC regardless of prior therapeutic failure

CHARLOTTE, N.C. — In a Healio video exclusive, David T. Rubin, MD, FACG, reported guselkumab induced greater improvement across key outcomes compared with placebo among patients with moderate to severe ulcerative colitis.Specifically, patients treated with guselkumab (Tremfya, Janssen) in the QUASAR phase 2b induction study demonstrated a greater clinical response at week 12 vs. placebo…

‘We should be better than this’: Health care industry flounders on paid family leave

For a growing number of Americans, 12 weeks of paid leave from work after the birth of a child, or to care for an ailing family member, is standard.For many health care providers, including physicians and nurses, the reality of paid leave is much different.“Many physicians do not have paid leave available,” Santina Wheat, MD,…

Prophylactic endotracheal intubation ‘should not be performed’ for upper GI bleeding

CHARLOTTE, N.C. — Prophylactic endotracheal intubation prior to endoscopy was not beneficial for patients with upper gastrointestinal bleeding and was instead tied to adverse risks, researchers reported at ACG 2022 Annual Scientific Meeting.“Many gastroenterologists commonly ask the ICU team to prophylactically intubate their patients with [upper GI bleeding (UGIB)] prior to endoscopy,” Syed Bilal Pasha,…

The unhealthy state of parental leave policies in gastroenterology: A call to action

Despite strong evidence of the mental and physical health benefits of paid parental leave on parents, children and the community, the Unites States is one of only six countries that does not offer it.This support for new parents is widely available outside the U.S, with Canada providing up to 40 weeks, many European countries offering…

Endoscopic fundoplication ‘should be considered’ for medication refractory GERD

CHARLOTTE, N.C. — Endoscopic fundoplication demonstrated comparable efficacy to its surgical counterpart in the treatment of patients with medication refractory GERD, according to a presentation at the ACG Annual Scientific Meeting.“Endoscopic procedures for medication refractory GERD have been available for a couple of decades now, but there have not been any studies comparing them to…

Same-day discharge after endoscopic submucosal dissection safe, ‘viable option’

CHARLOTTE, N.C. — Same-day discharge is a safe and feasible option for patients who undergo endoscopic submucosal dissection, according to a presentation at the ACG Annual Scientific Meeting.“Patients undergoing endoscopic submucosal dissection (ESD) have traditionally been admitted for routine post-procedural observation. In the COVID era, though, beds and staff are often in short supply,” William…

Better outcomes achieved with cap-assisted endoscopic removal for esophageal impaction

CHARLOTTE, N.C. — Cap-assisted endoscopic removal of an esophageal food bolus or foreign body impaction yielded better technical success, en-bloc removal and faster procedure time, noted a presenter at ACG 2022 Annual Scientific Meeting.“Recently, studies have reported favorable clinical outcomes with the use of a cap in the endoscopic retrieval of esophageal food bolus and/or…

Vonoprazan offers ‘complete, rapid, sustained’ relief in nonerosive reflux disease

CHARLOTTE, N.C. — Vonoprazan bested placebo for on-demand treatment of episodic heartburn in patients with nonerosive reflux disease and may offer an alternative to daily therapy, noted a presenter at the ACG Annual Scientific Meeting.“There is a need for noncontinuous therapy for GERD, especially by those with [nonerosive reflux disease (NERD)] and episodic heartburn,” Ronnie…