First patient treated in Takeda’s phase 3 trial for alpha-1 antitrypsin deficiency

Arrowhead Pharmaceuticals announced that the first patient has been treated in Takeda Pharmaceuticals’ phase 3 clinical trial of fazirsiran for the treatment of alpha-1 antitrypsin deficiency associated liver disease.Fazirsiran, an investigational RNA interference therapy intended to reduce the production of the mutant alpha-1 antitrypsin protein, was co-developed by both Takeda and Arrowhead. The drug was…

Laparoscopic gastrectomy could become ‘standard treatment’ for advanced gastric cancer

Laparoscopy-assisted distal gastrectomy with D2 lymph node dissection was noninferior to open distal gastrectomy in patients with locally advanced gastric cancer, according to 5-year follow-up data published in JAMA Surgery.“For advanced gastric cancer (AGC), laparoscopic gastrectomy is considered technically difficult owing to the large tumor size and lymph node metastasis. To clarify the safety and…