Rise in liver failures, transplants highlight need to curb high-risk drinking in all ages

CHICAGO — Researchers reported a 262% increase in liver transplantation for acute-on-chronic liver failure in older patients from 2005 to 2021, with alcohol-related liver disease becoming the leading cause during the COVID-19 pandemic.“Data on liver transplantation for acute-on-chronic liver failure (ACLF) in adults older than 65 years are currently limited,” Joseph J. Alukal, MD, assistant…

VIDEO: ‘Distinctive shift’ in gut microbiota after Rebyota treatment for C. difficile

CHICAGO — In a Healio video exclusive, Ken Blount, PhD, discusses successful restoration of gut microbiota and clonal engraftment as soon as 1 week after treatment with Rebyota in those with recurrent Clostridioides difficile infection.Blount and colleagues sought to quantify and define clonal engraftment and durable microbiome compositional changes with FDA-approved Rebyota (fecal microbiota, live-jslm/RBX2660,…

VIDEO: Patients with UC achieve symptomatic remission ‘as early as week 4’ with Tremfya

CHICAGO — In a Healio video exclusive, Jessica R. Allegretti, MD, MPH, explains that nearly 23% of patients with moderate to severe ulcerative colitis achieved clinical remission with Tremfya, compared with less than 10% on placebo.In a late-breaker presentation at Digestive Disease Week, Allegretti shared results from the QUASAR phase 3 induction study, which evaluated…

Alcohol-related cirrhosis worsened during pandemic, remains ‘top public health issue’

CHICAGO — Hospital admissions for alcohol-related cirrhosis jumped from March 2020 to March 2021, with associated increases in costs and mortality, according to study results presented at Digestive Disease Week.“The most striking finding from our study was the more than doubling in hospital admission for alcohol-related cirrhosis during the post-pandemic time period in both men…