Age may affect patient susceptibility to drug-induced liver injury

Age may affect patient susceptibility to drug-induced liver injury

Mitochondrial mechanisms of toxicity may be an important cause of drug-induced liver injury, according to a study published in Acta Pharmaceutica Sinica B.“This study examined liver injury reports submitted to the [FDA] Adverse Event Reporting System (FAERS) for drugs associated with hepatotoxicity via mitochondrial mechanisms compared with non-mitochondrial mechanisms of toxicity,” Payal Rana, Drug Safety Research & Development, Pfizer, and colleagues wrote.Rana and colleagues determined the frequency of hepatoxicity at both a group level and individual drug level. TheyRead More

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