Antibiotic use, certain gut bacteria affect CAR-T efficacy, toxicity

The use of broad-spectrum antibiotics in the month leading up to chimeric antigen receptor T-cell therapy led to poorer outcomes and increased treatment-related toxicities, study results showed.Certain types of gut bacteria had an impact on treatment efficacy and related toxicities among patients who received CAR-T for non-Hodgkin lymphoma or acute lymphoblastic leukemia, researchers reported.CAR T-cell therapies have produced “significant benefit for patients” in terms of overall response rates and survival, according to Melody Smith, MD, assistant professor of medicine in theRead More

Categories: News

Related Articles

Outpatient antibiotic management safe for select adults with acute appendicitis

Outpatient antibiotic management was safe compared with in-hospital care, with no greater risk for complications or appendectomy, in a subgroup of patients with acute appendicitis,…

Procalcitonin testing may reduce antibiotic use in acute pancreatitis

Procalcitonin-guided care reduced antibiotic use without increasing the risk for infection among patients with acute pancreatitis compared with standard care, according to research published in…

Antibiotic use linked with an increased risk for older-onset IBD

The use of antibiotics, particularly those targeting gastrointestinal pathogens, was associated with an increased risk for older-onset inflammatory bowel disease, according to a researcher at…

Algorithm that predicts viral etiology of diarrhea may curb inappropriate antibiotic use

Use of an algorithm-based tool to determine the likelihood of viral etiology for acute diarrhea in children did not significantly reduce antibiotic prescriptions in developing…

September 26, 2022

Hepatitis C incidence low among gay and bisexual men on PrEP, study finds

There were few incident hepatitis C virus infections recorded among gay and bisexual men participating in an HIV PrEP rollout study in Australia, researchers reported.The…