Antibiotic use, certain gut bacteria affect CAR-T efficacy, toxicity

The use of broad-spectrum antibiotics in the month leading up to chimeric antigen receptor T-cell therapy led to poorer outcomes and increased treatment-related toxicities, study results showed.Certain types of gut bacteria had an impact on treatment efficacy and related toxicities among patients who received CAR-T for non-Hodgkin lymphoma or acute lymphoblastic leukemia, researchers reported.CAR T-cell therapies have produced “significant benefit for patients” in terms of overall response rates and survival, according to Melody Smith, MD, assistant professor of medicine in theRead More