Delayed-release linaclotide improves abdominal pain in IBS-C

Patients with constipation-predominant irritable bowel syndrome treated with a delayed-release version of linaclotide experienced improvements in abdominal pain, according to study results.William D. Chey, MD, from the University of Michigan, and colleagues wrote that linaclotide is currently used in an immediate-release formula in IBS-C to improve bowel transit. However, it also could have an application for abdominal pain.“The hypersensitivity typical of IBS is likely complex and might be present throughout the GI tract; however, colonic sensory aerents appear key to the developmentRead More

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