Discovery of cell surface protein may lead to CAR-T for inflammatory diseases

Cellular senescence has both positive and negative effects in the body.The process can lead to tumor suppression and plays a key role in wound healing. However, it also can cause inflammation that results in long-term tissue damage and contributes to chronic diseases, such as liver fibrosis, lung cancer and osteoarthritis.A study published in Nature detailed the discovery of a urokinase-type plasminogen activator receptor (uPAR), a protein on the surface of cells that is present during senescence.Healio spoke with two of the study’s authors from Memorial Sloan Kettering Cancer Center —Read More