FDA grants fast track status to ervogastat plus clesacostat for NASH

The FDA has granted fast track designation to Pfizer for ervogastat in combination with clesacostat for treatment of patients with nonalcoholic steatohepatitis with liver fibrosis, according to a company press release.Pfizer’s investigational combination therapy targets key enzymes for the regulation of lipid metabolism, diacylglycerol O-acyltransferase 2 and acetyl-CoA carboxylase. Inhibiting these enzymes has previously been shown to lower liver fat in patients with nonalcoholic fatty liver disease, a benefit that Pfizer believes could be leveraged to improve inflammation andRead More

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