FDA limit on acetaminophen dosage linked to fewer hospitalizations, cases of liver failure

A 2011 FDA mandate, which limited acetaminophen dosage to 325 mg/tablet in prescription acetaminophen and opioid products, correlated with a decrease in yearly hospitalizations and cases of acute liver failure related to toxicity.“Anecdotally we had several patients in rapid succession with acetaminophen overdose — in the setting of taking over-the-counter flu/cold medications — requiring liver transplantation, and we wanted to understand FDA limits around dosing,” Jayme E. Locke, MD, MPH, FACS, FAST, director of the Comprehensive Transplant Institute at University ofRead More

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