IgA found in CSF during MS exacerbation could serve as neuroinflammation biomarker

Gut microbiota-specific immunoglobulin A cells acted as a systemic mediator in MS, according to findings published in Science Immunology — findings that also suggest “a critical role” for mucosal B cells during active neuroinflammation.“A previous paper in Cell, in which we also participated, described an unprecedented phenomenon in which immunoglobulin A (IgA) producing cells from the gut migrated to the brain to dampen inflammation in an experimental (murine) model of MS,” Sergio Baranzini, PhD, Distinguished Professor of Neurology I and Heidrich Friends andRead More

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