Minesapride safe, well-tolerated in IBS-C

Minesapride, an agonist of 5-hydroxytryptamine 4 receptor, was safe and well-tolerated among patients with constipation-predominant irritable bowel syndrome, according to study results.“Serotonin 4 (5-hydroxytryptamine 4 [5-HT4]) receptor agonists are believed to exert their therapeutic effect by acting on the 5-HT4 receptors in the gastrointestinal tract and lead to the release of acetylcholine, thereby promoting gastrointestinal motility,” Tatsuto Hamatani, of the drug development division at Sumitomi Dainippon Pharma Co, and colleagues wrote. “Minesapride has potentRead More

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