Mortality with two stress ulcer prophylaxis treatments did not differ in critically ill patients

Among critically ill patients requiring mechanical ventilation, 90-day in-hospital mortality rates did not differ significantly between those who received proton pump inhibitors and those who received histamine-2 receptor blockers for stress ulcer prophylaxis, new data published in JAMA indicate.Proton pump inhibitors (PPIs) are associated with various immunosuppressive effects that could lead to an increased risk for death from infections that commonly occur in the ICU, such as nosocomial pneumonia or Clostridioides difficile, according to the researchers.“The relative effect ofRead More

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