PAMORAs help achieve response in opioid-induced constipation

Peripherally acting mu-opioid receptor antagonists helped patients with opioid-induced constipation achieve therapeutic response, according to a meta-analysis published in Alimentary Pharmacology & Therapeutics.Michael Camilleri, MD, from Mayo Clinic in Rochester, Minnesota, and colleagues wrote that opioid-induced constipation can decrease treatment satisfaction and can lead patients to discontinue opioid therapy.“Mu-opioid receptors are expressed on enteric nerve cell bodies and facilitate potassium channel activation, membrane hyperpolarization and inhibition of ongoing neuralRead More