PAMORAs help achieve response in opioid-induced constipation

Peripherally acting mu-opioid receptor antagonists helped patients with opioid-induced constipation achieve therapeutic response, according to a meta-analysis published in Alimentary Pharmacology & Therapeutics.Michael Camilleri, MD, from Mayo Clinic in Rochester, Minnesota, and colleagues wrote that opioid-induced constipation can decrease treatment satisfaction and can lead patients to discontinue opioid therapy.“Mu-opioid receptors are expressed on enteric nerve cell bodies and facilitate potassium channel activation, membrane hyperpolarization and inhibition of ongoing neuralRead More

Share on facebook
Share on twitter
Share on linkedin