PPI use should be limited to appropriate indications, lowest effective dose in cirrhosis

Although proton pump inhibitors were linked with an increased risk for infection and decompensation in patients with cirrhosis, they may still be of benefit in those with prior gastrointestinal bleeding, according to published data.“In this study we found that proton pump inhibitor use was associated with liver-related adverse events that may mediate liver-related mortality,” Nadim Mahmud, MD, MS, MPH, MSCE, assistant professor of medicine and epidemiology at the University of Pennsylvania Perelman School of Medicine, told Healio. “However, in patients who had a priorRead More

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