Rare gene variants may increase risk for severe NAFLD in obesity

Rare gene variants may increase risk for severe NAFLD in obesity

Severe nonalcoholic fatty liver disease may be correlated with Autophagy Related Gene 7 loss-of-function variants, which may impair hepatocellular ballooning and inflammation.“We feel that the impaired ATG7 activity and autophagy are involved in pathogenesis of steatohepatitis in individuals with fatty liver disease,” Cristiana Bianco, MD, from Translational Medicine-department of transfusion medicine and Hematology-Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, said at the EASL NAFLD Summit. “Rare ATG7 variants are enriched in patients with severeRead More

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