RT-PCR yields high false-negative rates in early SARS-CoV-2 infection

Reverse transcriptase polymerase chain reaction, or RT-PCR, yielded a false negative rate as low as 20% and as high as 100%, according to a literature review and pooled analysis published in Annals of Internal Medicine.“The most important thing to take away from our study is that if clinicians have a very high suspicion that someone is infected — they had a very high risk exposure, or if they have symptoms that are very consistent with COVID-19 — then it’s important to treat them as positive even if you have a negative test result,” Lauren Kucirka, MD, PhD, studyRead More

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