Targetable landscape in pancreatic cancer varies greatly by KRAS status

CHICAGO — Potentially targetable oncogenic rearrangements are more prevalent among patients with KRAS wild-type pancreatic cancer than those with KRAS-mutated disease, according to study results presented at ASCO Annual Meeting.Homologous recombination deficiency, high tumor mutation burden and microsatellite instability-high disease also appeared more common in the KRAS wild-type population.In addition, early-onset pancreatic cancers — those diagnosed before age 50 years — appeared more likely to be KRAS wild-type, exhibit homologous recombination deficiency phenotype andRead More

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