Prophylactic antibiotics do not reduce mortality in severe alcohol-related hepatitis

The use of amoxicillin-clavulanate with prednisolone did not improve 2-month survival compared with prednisolone alone in patients hospitalized with severe alcohol-related hepatitis, according to data in JAMA.“Patients with severe alcohol-related hepatitis are at increased risk for bacterial and fungal infection,” Alexandre Louvet, MD, of the University of Lille in France, and colleagues wrote. “Approximately 25% to 30% of patients with severe alcohol-related hepatitis develop infection during corticosteroid treatment. Patients who develop infection while receivingRead More