‘Three-way interaction’ found between HLA-B27, male sex, sacroiliitis development in IBD

CHICAGO — In patients with inflammatory bowel disease, a “strong and consistent three-way interaction” was identified between HLA-B27, male sex and the development of sacroiliitis, according to data presented at Digestive Disease Week.Sacroiliitis occurs in approximately 20% of patients with IBD, often aligned with male sex and HLA-B27 status; however, large-scale studies on the pathogenesis of this extraintestinal manifestation of IBD are still lacking.“Our interest is the overlap of immune-mediated inflammatory diseases,” Dermot McGovern, MD, PhD, director ofRead More