Combination glecaprevir, pibrentasvir with ezetimibe prevents HCV in transplantation

LONDON — Combined glecaprevir and pibrentasvir with ezetimibe prevented hepatitis C infection among patients who received non-liver solid organ transplants with HCV viremic grafts, according to research.“We have an availability of safe, well-tolerated and highly effective hepatitis C therapies with direct acting antiviral agents,” Bashar Aqel, MD, a gastroenterologist and transplant hepatologist at the Mayo…

HCV reinfection prevalence rises among MSM as acute cases decline

LONDON — Although the annual incidence of acute hepatitis C virus has decreased over the past 10 years in Frankfurt, Germany, the prevalence of HCV genotype 4 increased in men who have sex with men, according to research.“Despite the broad availability of direct acting antivirals, ongoing transmission of HCV, as well as a persistent epidemic…

Environmental hygiene program halved nosocomial C. difficile infections

An environmental hygiene program meant to improve cleaning thoroughness led to a sustained 50% decrease in health care-onset Clostridioides difficile infection in eight hospitals, a study found.“[This study was prompted by] the limited impact of traditional approaches to mitigating C. difficile transmission in acute-care hospitals,” Philip C. Carling, MD, clinical professor of medicine at the…

Younger-onset type 2 diabetes increases risk for liver-related events

LONDON — Younger-onset type 2 diabetes increased the risk for liver-related events among patients with nonalcoholic fatty liver disease, according to research presented at the International Liver Congress.“Earlier this year, we reported that among patients with NAFLD and type 2 diabetes, over 90% developed cirrhotic complications and hepatocellular carcinoma after the age of 50. Meanwhile,…

Bulevirtide monotherapy safe, well-tolerated in chronic hepatitis D patients

LONDON — Bulevirtide induced a greater combined virologic and biochemical response compared with control at 48 weeks in patients with chronic hepatitis D infection, according to research.“HDV causes the most severe form of chronic viral hepatitis with two-to-three-fold increased risk for mortality compared with HBV mono-infection,” Heiner Wedemeyer, PhD, professor and clinical director of gastroenterology,…

Gender-Equity Model for Liver Allocation more accurately predicts mortality vs. MELD

LONDON — The Gender-Equity Model for Liver Allocation and its sodium-corrected variant were better predictors of mortality or delisting in patients awaiting liver transplantation and may correct gender disparities, according to research.“The odds of delisting for sickness in women are 30% higher than in men, and this may have something to do with serum creatinine,”…