Heavy alcohol use, gene variant heighten risk for HCC, mortality in HBV-related cirrhosis

Patients with cirrhosis who have hepatitis B virus infection and a history of heavy alcohol use are at higher risk for hepatocellular carcinoma and mortality, according to a study published in JAMA Network Open.As previously reported, heavy consumption of alcohol increases risk for HCC among patients with cirrhosis and HBV. Aldehyde dehydrogenase 2 gene (ALDH2) polymorphism also has been reported to play a role in HCC development, although study results have been mixed.“However, the roles of heavy alcohol intake, ALDH2 rs671 polymorphism and HBV infection in the development of HCC andRead More

Related Articles