Rare germline mutations in CIDEB gene protect against liver disease, damage

In one of the largest exome-sequencing studies on liver health, researchers found rare genetic loss-of-function variants in the CIDEB gene were associated with significant protection from liver damage and disease.The discovery, recently published in The New England Journal of Medicine, is “a milestone in our understanding of the genetic basis of nonalcoholic steatohepatitis,” Luca A. Lotta, MD, PhD, vice president and head of cardiometabolic and musculoskeletal disease genetics at Regeneron and study co-author, told Healio.“In this study, one in every 700 individuals whoRead More

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